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kat2a sg2 plasmid  (Mirus Bio)


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    Structured Review

    Mirus Bio kat2a sg2 plasmid
    (A) Diagram of members of the SAGA complex that were identified in the TurboID-MS dataset. Colors indicate enrichment in the TAp63 γ ; interactome compared to the ΔNp63 γ ; interactome. The log 2 FC of normalized spectral counts is written inside each circle. (B) Coimmunoprecipitation of FLAG-tagged p63 isoforms with GFP-tagged <t>KAT2A.</t> (C) FINCHES protein-protein interaction predictions between TAp63 γ ; or ΔNp63 γ ; and KAT2A. (D) Luminescence values of caspase 3/7 activation in PCI-30 cells induced to express TAp63 γ ; and treated with 5uM GSK-699 for 72 hours. Immunoblot of KAT2A and KAT2B following different concentrations of GSK-699 below.
    Kat2a Sg2 Plasmid, supplied by Mirus Bio, used in various techniques. Bioz Stars score: 99/100, based on 8512 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/kat2a+sg2+plasmid/TransIT+-LT1/bio_rxiv__64898__2026__04__19__719484-62-9-13
    Average 99 stars, based on 8512 article reviews
    kat2a sg2 plasmid - by Bioz Stars, 2026-10
    99/100 stars

    Images

    1) Product Images from "Isoform-specific cofactor recruitment through the intrinsically disordered N-terminus of p63 underlies differential transcriptional activities"

    Article Title: Isoform-specific cofactor recruitment through the intrinsically disordered N-terminus of p63 underlies differential transcriptional activities

    Journal: bioRxiv

    doi: 10.64898/2026.04.19.719484

    (A) Diagram of members of the SAGA complex that were identified in the TurboID-MS dataset. Colors indicate enrichment in the TAp63 γ ; interactome compared to the ΔNp63 γ ; interactome. The log 2 FC of normalized spectral counts is written inside each circle. (B) Coimmunoprecipitation of FLAG-tagged p63 isoforms with GFP-tagged KAT2A. (C) FINCHES protein-protein interaction predictions between TAp63 γ ; or ΔNp63 γ ; and KAT2A. (D) Luminescence values of caspase 3/7 activation in PCI-30 cells induced to express TAp63 γ ; and treated with 5uM GSK-699 for 72 hours. Immunoblot of KAT2A and KAT2B following different concentrations of GSK-699 below.
    Figure Legend Snippet: (A) Diagram of members of the SAGA complex that were identified in the TurboID-MS dataset. Colors indicate enrichment in the TAp63 γ ; interactome compared to the ΔNp63 γ ; interactome. The log 2 FC of normalized spectral counts is written inside each circle. (B) Coimmunoprecipitation of FLAG-tagged p63 isoforms with GFP-tagged KAT2A. (C) FINCHES protein-protein interaction predictions between TAp63 γ ; or ΔNp63 γ ; and KAT2A. (D) Luminescence values of caspase 3/7 activation in PCI-30 cells induced to express TAp63 γ ; and treated with 5uM GSK-699 for 72 hours. Immunoblot of KAT2A and KAT2B following different concentrations of GSK-699 below.

    Techniques Used: Activation Assay, Western Blot

    Related Articles

    Transfection:

    Article Title: Isoform-specific cofactor recruitment through the intrinsically disordered N-terminus of p63 underlies differential transcriptional activities
    Article Snippet: For the KAT2A CRISPR knockout, we purchased lentiCRISPRv2 sgControl (Addgene, plasmid #125836) and lentiCRISPRv2 KAT2A sg2 (Addgene, plasmid #138186). .. We transfected PCI-30 with the control plasmid and the KAT2A sg2 plasmid using Mirus TransIT-LT1 (Mirus, MIR2305). .. We transfected PCI-30 with the control plasmid and the KAT2A sg2 plasmid using Mirus TransIT-LT1 (Mirus, MIR2305).

    Control:

    Article Title: Isoform-specific cofactor recruitment through the intrinsically disordered N-terminus of p63 underlies differential transcriptional activities
    Article Snippet: For the KAT2A CRISPR knockout, we purchased lentiCRISPRv2 sgControl (Addgene, plasmid #125836) and lentiCRISPRv2 KAT2A sg2 (Addgene, plasmid #138186). .. We transfected PCI-30 with the control plasmid and the KAT2A sg2 plasmid using Mirus TransIT-LT1 (Mirus, MIR2305). .. We transfected PCI-30 with the control plasmid and the KAT2A sg2 plasmid using Mirus TransIT-LT1 (Mirus, MIR2305).

    Plasmid Preparation:

    Article Title: Isoform-specific cofactor recruitment through the intrinsically disordered N-terminus of p63 underlies differential transcriptional activities
    Article Snippet: For the KAT2A CRISPR knockout, we purchased lentiCRISPRv2 sgControl (Addgene, plasmid #125836) and lentiCRISPRv2 KAT2A sg2 (Addgene, plasmid #138186). .. We transfected PCI-30 with the control plasmid and the KAT2A sg2 plasmid using Mirus TransIT-LT1 (Mirus, MIR2305). .. We transfected PCI-30 with the control plasmid and the KAT2A sg2 plasmid using Mirus TransIT-LT1 (Mirus, MIR2305).



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    kat2a sg2 plasmid  (Mirus Bio)
    99
    Mirus Bio kat2a sg2 plasmid
    (A) Diagram of members of the SAGA complex that were identified in the TurboID-MS dataset. Colors indicate enrichment in the TAp63 γ ; interactome compared to the ΔNp63 γ ; interactome. The log 2 FC of normalized spectral counts is written inside each circle. (B) Coimmunoprecipitation of FLAG-tagged p63 isoforms with GFP-tagged <t>KAT2A.</t> (C) FINCHES protein-protein interaction predictions between TAp63 γ ; or ΔNp63 γ ; and KAT2A. (D) Luminescence values of caspase 3/7 activation in PCI-30 cells induced to express TAp63 γ ; and treated with 5uM GSK-699 for 72 hours. Immunoblot of KAT2A and KAT2B following different concentrations of GSK-699 below.
    Kat2a Sg2 Plasmid, supplied by Mirus Bio, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/kat2a+sg2+plasmid/TransIT+-LT1/bio_rxiv__64898__2026__04__19__719484-62-9-13
    Average 99 stars, based on 1 article reviews
    kat2a sg2 plasmid - by Bioz Stars, 2026-10
    99/100 stars
    		  Buy from Supplier

    Image Search Results


    (A) Diagram of members of the SAGA complex that were identified in the TurboID-MS dataset. Colors indicate enrichment in the TAp63 γ ; interactome compared to the ΔNp63 γ ; interactome. The log 2 FC of normalized spectral counts is written inside each circle. (B) Coimmunoprecipitation of FLAG-tagged p63 isoforms with GFP-tagged KAT2A. (C) FINCHES protein-protein interaction predictions between TAp63 γ ; or ΔNp63 γ ; and KAT2A. (D) Luminescence values of caspase 3/7 activation in PCI-30 cells induced to express TAp63 γ ; and treated with 5uM GSK-699 for 72 hours. Immunoblot of KAT2A and KAT2B following different concentrations of GSK-699 below.

    Journal: bioRxiv

    Article Title: Isoform-specific cofactor recruitment through the intrinsically disordered N-terminus of p63 underlies differential transcriptional activities

    doi: 10.64898/2026.04.19.719484

    Figure Lengend Snippet: (A) Diagram of members of the SAGA complex that were identified in the TurboID-MS dataset. Colors indicate enrichment in the TAp63 γ ; interactome compared to the ΔNp63 γ ; interactome. The log 2 FC of normalized spectral counts is written inside each circle. (B) Coimmunoprecipitation of FLAG-tagged p63 isoforms with GFP-tagged KAT2A. (C) FINCHES protein-protein interaction predictions between TAp63 γ ; or ΔNp63 γ ; and KAT2A. (D) Luminescence values of caspase 3/7 activation in PCI-30 cells induced to express TAp63 γ ; and treated with 5uM GSK-699 for 72 hours. Immunoblot of KAT2A and KAT2B following different concentrations of GSK-699 below.

    Article Snippet: We transfected PCI-30 with the control plasmid and the KAT2A sg2 plasmid using Mirus TransIT-LT1 (Mirus, MIR2305).

    Techniques: Activation Assay, Western Blot